House: "Do you notice how all the self-sacrificing women in history; Joan of Arc, Mother Theresa, can't think of any others; they all die alone. The men, on the other hand, get so much fuzz, it's crazy."
House: "There's an evolutionary imperative why we give a crap about our family and friends. And there's an evolutionary imperative why we don't give a crap about anybody else. If we loved all people indiscriminately, we couldn't function."
House: "Lies are like children: they're hard work, but it's worth it because the future depends on them."
House: "Gifts allow us to demonstrate exactly how little we know about a person. And nothing pisses a person off more than being shoved into the wrong pigeonhole."
House: "You can have all the faith you want in spirits, and the afterlife, and heaven and hell, but when it comes to this world, don't be an idiot. Cause you can tell me you put your faith in God to put you through the day, but when it comes time to cross the road, I know you look both ways."
House: "Why would you support someone who screws up?"
Cameron: "Because I'm not insanely insecure. And because I can actually trust in another human being, and I am not an angry, misanthropic son of a bitch."
House: "I'm sorry, you said you weren't angry."
Cuddy: "You know, there are other ways to manage pain."
House: "Like what, laughter? Meditation? Got a guy who can fix my third chakra?"
House: "I've been alienating people since I was three."